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Knee Arthritis: Diagnostic Imaging Approaches II | El Paso, TX.

Sagittal Fluid Sensitivity

knee arthritis chiropractic care el paso tx.
  • Sagittal Fluid Sensitive MR slice showing large synovial popliteal (Baker’s) cyst (above top image) and large synovial effusion (above bottom image)
  • Note multiple patchy dark signal areas on both images, representing fibrinoid inflammatory depostits aka “rice bodies” a characteristic MRI feature of RA

Management Rheumatological Referral & DMARM

Septic Arthritis (SA)

  • Clinically: may vary and depends on host immune response and bacterial virulence. May present with rapid onset or exacerbation of pre-existing joint pain, swelling, limitation of ROM. General signs of malaise, fever, fatigue and elevated ESR, CRP, Leucocytosis may be present.
  • N.B. Diabetics and immunocompromised may present with fewer manifistations and lack of fever d/t declining immune response
  • Dx: clinical, radiological and laboratory. Arthrocentesis may be necessary for culture, cell count and purulent synovial examination
  • Management: I.V. antibiotics
  • Imaging Dx: begins with radiography but in the early stage most likely will be unremarkable. MRI can be sensitive and help with early identification of joint effusion, bone edema etc. US may be helpful in the superficial joints and in children. US helps with needle guidance. Bone scintigraphy may be used occaisonally if MRI is contraindicated

Routes of Joint Contamination

knee arthritis chiropractic care el paso tx.
  • 1. Hematogenous (M/C)
  • 2. Spread from the adjacent site
  • 3. Direct inoculation
  • M/C organism-Staph aureus
  • N.B Gonococcal infection may be a top differential in some cases
  • IV drug users: pseudomonas, candida
  • Sickle cell: Salmonella
  • Animal (cats/dogs) bites: Pasteurella
  • Occaisonally fungal contamination may occur
knee arthritis chiropractic care el paso tx.

Radiography

knee arthritis chiropractic care el paso tx.
  • Initially non-specific ST/joint effusion, obscuration/distortion of fat planes. Because it takes 30% of compact and 50-75% trabecula bone to be destroyed before seen on x-rays, radiography is insensitive to some of the early changes. MR imaging is the preferred modality
  • If MRI is not available or contraindicated. Bone scintigraphy with Tc-99 MDT can help
  • In children US preferred to avoid ionizing radiation. In children US can be more sensitive than in adults due to lack of bone maturation

Radiographic Dx

knee arthritis chiropractic care el paso tx.
  • Early findings are unrewarding. Early features may include: joint widening d/t effusion. Soft tissue swelling and obscuration/displacement of fat planes
  • 1-2 weeks: periarticular and adjacent osseous changes manifesting as patchy demineralization, moth-eaten, permeating bone destruction, loss and indistinctness of the epiphyseal “white cortical line” with increase in soft tissue swelling. MRI may be helpful with early Dx.
  • Late features: complete joint destruction and ankyloses
  • N.B. Septic arthritis may progress rapidly within days and requires early I.V. antibiotic to prevent major joint destruction

T1 & T2 Knee MRI

knee arthritis chiropractic care el paso tx.
  • T1 (above left) and T2 fat-sat sagittal knee MRI slices reveal loss of normal marrow signal on T1 and increase on T2 due to septic edema. Bone sequestrum d/t osteomyelitis progressing into septic arthritis is noted. Marked joint effusion with adjacent soft tissue edema are seen. Dx: OSM and septic arthritis

Crystal-Induced Knee Arthritis

  • Crystalline arthritis: a group of arthropathies resulting from crystal deposition in and around the joint.
  • 2-m/c: Monosodium urate crystals (MSU)  and Calcium Pyrophosphate Dehydrate crystals (CPPD) arthropathy 
  • Gout: MSU deposition in and around joints and soft tissues. Elevated levels of seurm uric acid (UA) (>7mg/dL) causd by overproduction or under-excretion of uric acid
  • Once UA reached/exceeded 7mg/dL it will deposit in the peripheral tissues. Primary gout: disturbed metabolism of nucleic acids and purines breakdown. Secondary gout: increased cell turnover: Psoriasis, leukemia, multiple myeloma, hemolysis, chemotherapy etc.
  • Gout presents with 5-characteristic stages:
  • 1)asymptomatic hyperuricemia (years/decades)
  • acute attacks of gouty arthritis (waxes and wanes and lasts for several years)
  • Interval phase between attacks
  • Chronic tophacious gout
  • Gouty nephropathy
knee arthritis chiropractic care el paso tx.

Clinical Presentation

  • Depends  on stages
  • Acute attacks: acute joint pain “first and the worst” even painful to light touch
  • DDx: septic joint (both may co-exist) bursitis etc.
  • Gouty arthritis typically presents as monoarthropathy
  • Chronic tophacious stage: deposits in joints, ear pinna, ocular structures and other regions. Nephrolithiasis etc. Men>women. Obesity, diet, and age >50-60.
  • Radiography: early attacks are unremarkable and may present as non-specific joint effusion
  • Chronic tophacious gout radiography: punched out peri-articular, para-aticular and/or intraosseous erosions with overhanging edges. Characteristic rim of sclerosis and internal calcification, soft tissue tophi. Target sites: lower extremity m/c
  • Rx: allopurinol, colchicin (esp. preventing acute episodes and maintenance)

Synovial Aspiration

knee arthritis chiropractic care el paso tx.
  • Synovial aspiration with polarized microscopy reveal negatively birefringent needle-shaped MSU crystals with large inflammatory PMN presence. DDx: positively birefringent rhomboid-shaped CPPD crystals (above bottom right) seen in Pseudogout and CPPD
knee arthritis chiropractic care el paso tx.

Large S.T.

knee arthritis chiropractic care el paso tx.
  • Density and joint effusion puched out osseous erosion with overhanging margins, overall perservation of bone density, internal calcifications Dx: chronic tophacious gout

MRI Gout Features

knee arthritis chiropractic care el paso tx.
  • Erosions with overhanging margins, low signal on T1 and high on T2 and fat suppressed images. Peripheral contrast enhancement of tophacious deposits d/t granulation tissue
  • Dx: final Dx; synovial aspiration and polarized microscopy

Additional Articles

Knee Arthritis

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