PUSH Fitness & Rehabiliation
Welcome !! PUSH-as-Rx ®™ is leading the field with laser focus supporting our youth sport programs. The PUSH-as-Rx ®™ System is a sport specific athletic program designed by a strength-agility coach and physiology doctor with a combined 40 years of experience working with extreme athletes. At its core, the program is the multidisciplinary study of reactive agility, body mechanics and extreme motion dynamics. Through continuous and detailed assessments of the athletes in motion and while under direct supervised stress loads, a clear quantitative picture of body dynamics emerges. Exposure to the biomechanical vulnerabilities are presented to our team. Immediately, we adjust our methods for our athletes in order to optimize performance. This highly adaptive system with continual dynamic adjustments has helped many of our athletes come back faster, stronger, and ready post injury while safely minimizing recovery times. Results demonstrate clear improved agility, speed, decreased reaction time with greatly improved postural-torque mechanics. PUSH-as-Rx ®™ offers specialized extreme performance enhancements to our athletes no matter the age.

Is It Really Autoimmunity? | El Paso, TX. | Part II

Autoimmunity: One of the most common things is to leave the doctor’s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping  the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.

Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?

 

autoimmunity el paso tx.
http://science.sciencemag.org/content/330/6003/460.summary?sid=1ab5a992-4406-499c-b24f-6e7a46c1dc95

autoimmunity el paso tx.

The Exposome

autoimmunity el paso tx.

autoimmunity el paso tx.Semin Arthritis Rheum. 2018; 47(5): 710‐717.

Exposome Influence On SLE

autoimmunity el paso tx.The Ecology Of The Exposome

autoimmunity el paso tx.Exposome & The Alteration Of “Self”

autoimmunity el paso tx.The Exposome Connections To Autoimmune Diseases Converting Self Into Non‐Self

  • Immunometabolic dysfunctions through diet and lifestyle imbalances
  • Gut Ecology and the Microbiome
  • ViralorBacterialInfections
  • Hormones
  • Drugs
  • Chemicals
  • IonizingRadiation
  • PsychologicalStress

autoimmunity el paso tx.FEBS Lett. 2017 Oct;591(19):3119‐3134.

autoimmunity el paso tx.Cell. 2018 Jan 11;172(1‐2):22‐40.

Cross‐Talk Among The Endocrine, Immune & Metabolic Systems

autoimmunity el paso tx.Multi‐Organ Network Biology

autoimmunity el paso tx.In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH

autoimmunity el paso tx.Science. 2018; 360: 377‐78. Dietary Influence?

Blocking Immune Cell Glycolysis & “Starving” Its Function

autoimmunity el paso tx.Science. 2018; 360: 449‐54.

Ketogenic Diet’s Potential Impact On GAPDH Immunometabolic Regulation

autoimmunity el paso tx.

autoimmunity el paso tx.Cell. 2018 Jan 11;172(1‐2):162‐175.

autoimmunity el paso tx.Gut Microbes. 2016;7(1):82‐9.

autoimmunity el paso tx.

autoimmunity el paso tx.Front Immunol. 2017 Mar 21;8:311.

autoimmunity el paso tx.Origin Of IL‐17 Producing Th17 Cells

autoimmunity el paso tx.What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?

autoimmunity el paso tx.
https://www.cell.com/cell/issue?pii=S0092-8674(17)X0006-8

autoimmunity el paso tx.Science. 2018 Mar 9;359(6380):1097‐98.

autoimmunity el paso tx.

autoimmunity el paso tx.Science. 2018 Mar 9;359(6380):1156‐61.

autoimmunity el paso tx.Allergol Int. 2018 Jan 6;67(1):32‐42.

autoimmunity el paso tx.Int J Mol Sci. 2015 Sep 1;16(9):20841‐58.

autoimmunity el paso tx.Science. 2018 Mar 9;359(6380):1151‐56.

High Fiber Influences On Diabetes In Animal Model

autoimmunity el paso tx.80% Of Patients With Autoimmune Disease Are Female

Why?

Estrogen & Autoimmunity

autoimmunity el paso tx.

  • The greatest association with autoimmune diseases is the female gender
  • 17‐beta estradiol seems to play a role in activating T cells in autoimmune disease
  • T cells have ER‐alpha receptors that are activated by 17‐beta estradiol resulting in the production of inflammatory cytokines
  • Blocking ER‐alpha receptors may have a beneficial effect on autoimmune activation

Sci Signal. 2018 Apr 17;11(526). piieaap 9415

Eleanor Rogan, PhD IFM Linus Pauling Award Winner

autoimmunity el paso tx.www.JeffreyBland.com

Estrogen & Androgen Metabolism

autoimmunity el paso tx.4‐Hydroxyestrogens & DNA reactivity

autoimmunity el paso tx.

autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pubmed/22155198
autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pubmed/21432907

Indole‐3‐Carbinol (I3C) Inhibition Of ER‐Alpha

autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pubmed/27312859

autoimmunity el paso tx.Relationship Of Hepatic Drug Detoxification To Anti‐Nuclear Antibody Development

autoimmunity el paso tx.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780240805
autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pubmed/24763537

autoimmunity el paso tx.Biomed Res Int. 2015;2015:194031.

autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365752/
autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pubmed/18995849
autoimmunity el paso tx.
https://www.ncbi.nlm.nih.gov/pubmed/24530186

Making Friends With Ourselves: Clinical Implications

  • Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
  • – Dietary
  • – Infection
  • – Parasites
  • – Xenobiotics
  • – Hormone
  • – Allergy
  • – Specific medications
  • – Dysbiosis
  • Reduce exposure to DNA damage (radiation, chemicals)
  • Support hepatic detoxification
  • Implement gastrointestinal restoration program
  • Reduce metabolic inflammation and endotoxin
  • Reduce psychological stress factors that activate HPA axis

 

Jeffrey Bland, PhD

Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine

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